This report is about how Ghana is undergoing transformations on several fronts including, the transition to middle income country status; public and private sector reform, information and communication advancements; increasing urbanization, and several others. Undoubtedly, these changes cut across the socio-economic fiber of the development structures and have implications for governmental and Non-governmental or Non-Profit organizations (NPOs). Non-Profit Organisations are been recognized by the government as significant partners as well as a valuable force in promoting and consolidating sustainable national development.