The US 2022 midterm elections will have a significant impact on the Biden administration’s ability to implement its program at home and abroad in the next two years. The new balance in Congress will redefine US domestic priorities as well as influence US Multilateralism;, in particular in the context of the Russian invasion of Ukraine. The results of the elections open a new chapter for transatlantic cooperation, and understanding the potential challenges and opportunities is key for allies to design the relationship going forward.